The School of Fashion Design was founded in 1934 by Carolyn L. Dewing and Donald Smith-Fedey as the Modern School of Applied Art. In 1936, Dorchester native Isobel Sinesi joined the faculty and was instrumental in adding fashion design to the curriculum. Serving as co-director from 1952 until her death in 1997, Sinesi led the school in developing its curriculum to focus entirely on fashion design.
The School of Fashion Design moved in 2022 and is now located at 31 St James Avenue.